Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Introduction: Febrile seizures (FSs) are caused by the simultaneous consumption of first- and second-generation antihistamines, which prolong process in some cases. Objectives: The present study aimed to evaluate relationship between seizure susceptibility type antihistamines patients with FS. Patients Methods: This retrospective cohort was conducted on 364 children FS admitted Taleghani Hospital Gorgan, Iran 2020. subjects were selected via convenience sampling divided into two groups antihistamine non-users based their medical files. Data analysis performed SPSS16 using descriptive statistics chi-square, independent t-test, Mann-Whitney U test, relative risk. Results: mean age 22.77±14.91 months (6-60 months). 56.1% male. Antihistamine prescribed for 15.6% subjects, interval fever onset shorter group (P=0.37). On other hand, duration significantly longer (P=0.049). risk a lasting more than five minutes 1.14 times higher first-generation compared (P=0.078). Conclusion: According results, history use during febrile period experienced seizure, significant observed severity use. In addition, group. Therefore, this class drugs range should be limited prescription specialist.